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US 8,772,319 B2Granted
Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process
AssigneeThe General Hospital Corporation
InventorsDavid R. Elmaleh, Choi Sungwoon, Alan J. Fischman
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Abstract
Described herein are piperidine and piperazine compounds useful for treating neurodegenerated diseases characterized by a lack of dopamine neuron activity. The compounds are also useful for imaging dopamine neurons.
Claims20
A compound of Formula IV
- wherein:
- m is an integer of 1 to 6;
- B is —O—, —N(H)—, —C(═O)N(H)—, or —N(H)C(═O)—;
- X and Y can be the same or different and are selected from the group consisting of hydrogen, halo, haloalkyl, alkyl, aryl, (C1-C6)alkoxy, —SH, and —SR;
- R is optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, or optionally substituted 1,2,4-oxadiazol-5-yl;
- and
- V is hydrogen, —C(═O)N(H)-aryl, —C(═O)-alkyl, —SO2-aryl, alkyl, alkenyl, alkynyl, haloaryl, or alkyl halophenyl, wherein aryl or alkyl is optionally substituted.
4 more elements
Dependencies are inferred from the claim text.