Aqueous pharmaceutical suspensions containing rebamipide and manufacturing process thereof
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorYoshito Masuda
Life of this patent
Estimating the term…
Abstract
The invention provides a rebamipide-containing aqueous pharmaceutical suspension which can be prepared by a simple process and keep the dispersed fine-particle state of rebamipide stable without having the fine particle agglutinated. The rebamipide-containing aqueous pharmaceutical suspension of the invention is prepared by mixing polyvinyl alcohol and additionally a sodium salt compound with rebamipide.
Claims5
An aqueous suspension comprising fine particles of rebamipide having a mean particle size ranging from 0.2 μm to 5 μm and polyvinyl alcohol.
A process for the preparation of an aqueous suspension comprising rebamipide, which comprises
- (1) mixing water and polyvinyl alcohol to prepare an aqueous solution containing polyvinyl alcohol, and
- (2) adding fine particles of rebamipide having a mean particle size ranging from 0.2 μm to 5 μm to the aqueous solution containing polyvinyl alcohol and mixing to give the aqueous suspension comprising rebamipide.
Dependencies are inferred from the claim text.