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US 8,772,312 B2Granted
Heterocyclic compounds as CRTH2 receptor antagonists
AssigneesCspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd., Centaurus Biopharma Co., Ltd.
InventorWei W. Yuan
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Abstract
This application relates to a compound of Formula ! (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an antagonist of receptor CRTH2, as well as a process for its preparation and intermediates therefor.
Claims15
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- A is N and B, C, and D are independently selected from CH and C(R1);
- m is an integer from 1 to 4;
- n is an integer from 0 to 4;
- R1 is halogen;
- R2 and R3 are hydrogen;
- R4 is selected from H, C1-6 alkyl;
- Ar is aryl optionally substituted with one or more halogen atoms;
- X is —C(Ra)(Rb)—, wherein Ra and Rb are H;
- Y is —S(O)2—.
7 more elements
Dependencies are inferred from the claim text.