Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof

A method for treating at least one of depression and anxiety in a mammal comprising administering to a mammal in need thereof an effective amount of a piperazine compound represented by Formula (I):

• or pharmaceutically acceptable salts thereof,
• wherein
• n is an integer from 2 to 6;
• R1 and R2 are the same or different and are independently selected from the group consisting of hydrogen, a hydroxyl group, a halogen, nitrogen dioxide, a straight or branched chain-alkyl group with 1 to 4 carbon atoms, and a straight or branched chain alkoxy group with 1 to 4 carbon atoms;
• R3 is a C1-C2 alkylene;
• and
• R4 is selected from the group consisting of:
• (a) a C2-C6 dialkylamine,
• (b) a 5 to 9-membered aromatic amine wherein the ring is independently substituted with at least one of hydrogen, a C1-C6 aliphatic alkyl, a C3 to C10 cyclic alkyl, a C6-C10 aryl group and a halogen,
• (c) a 5 to 9-membered heteroaromatic amine comprising at least a nitrogen atom as a ring constituent wherein the ring is independently substituted with at least one of hydrogen, a C1-C6 aliphatic alkyl, a C3 to C10 cyclic alkyl, a C6-C10 aryl group and a halogen,
• (d) a 5 to 9-membered heterocyclic ring comprising at least a nitrogen atom as a ring constituent wherein the ring is independently substituted with at least one of hydrogen, a C1-C6 aliphatic alkyl, a C3 to C10 cyclic alkyl, a C6-C10 aryl group and a halogen, and
• (e) a 5 to 9-membered heteroaromatic ring comprising at least a nitrogen atom as a ring constituent wherein the ring is independently substituted with at least one of hydrogen, a C1-C6 aliphatic alkyl, a C3 to C10 cyclic alkyl, a C6-C10 aryl group and a halogen;
• and
• R4 is connected to R3 group through a nitrogen atom therein,
• wherein R4 is not morpholine.