Benzamide derivatives and uses related thereto

A compound having the formula (I):

• or pharmaceutically acceptable salts, solvates, stereoisomers or prodrugs thereof,
• wherein:
• n is 0;
• R1 is a member selected from the group consisting of —OH, halogen and (C1-C8)haloalkyl;
• R2 and R3 are members independently selected from the group consisting of halogen, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)alkoxy, (C1-C8)haloalkyl, (C2-C8)hydroxyalkyl and (C3-C8)cycloalkyl, wherein no more than two of R1, R2 and R3 are halogen;
• R4 is a member selected from the group consisting of hydrogen, halogen, (C1-C8)alkyl and (C3-C8)cycloalkyl;
• R5 is selected from the group consisting of (C1-C8)alkyl, (C1-C8)haloalkyl, (C2-C8)hydroxyalkyl, (C3-C8)cycloalkyl, and (C3-C8)heterocycloalkyl;
• R6 is selected from the group consisting of (C2-C8)alkenyl, (C1-C8)haloalkyl, aryl(C1-C6)alkyl, (C3-C8)cycloalkyl, (C3-C8)heterocycloalkyl, heteroaryl, and aryl;
• wherein each aryl and heteroaryl group is optionally substituted by substituents numbering from one to the number of open valences on the aryl or heteroaryl group selected from the group consisting of -halo, —OR′, —OC(O)R′, —NR′R″, —SR′, —R′, —CN, —NO2, —CO2R′, —C(O)NR′R″, —C(O)R′, —OC(O)NR′R″, —NR″C(O)R′, —NR″CO2R′, —NR′″C(O)NR′R″, —NR′″SO2NR′R″, —NHC(NH2)═NH, —NR′C(NH2)═NH, —NH—C(NH2)═NR′, —S(O)R′, —SO2R′, —SO2NR′R″, —NR″SO2R′, —N3, —CH(Ph)2, perfluoroalkoxy and perfluoro(C1-C4)alkyl;
• wherein R5 or R6 is optionally substituted with from one to two members selected from the group consisting of halogen, —CN, —NO2, (C1-C4)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C4)alkoxy, (C1-C4)haloalkyl, (C2-C4)hydroxyalkyl, —C(O)R′, —C(O)OR′, —NR′C(O)OR′, —OR′, —SR′, —OC(O)R′, —C(O)N(R′)2, —S(O)R′, —SO2R′, —SO2N(R′)2, —N(R′)2, —NR′C(O)R′ and —NR′ SO2R′;
• R7 is selected from the group consisting of —CN, (C2-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)haloalkyl, (C1-C8)hydroxyalkyl, —C(O)R′, —C(O)OR′, —NR′C(O)OR′, —OR′, —OC(O)R′, —C(O)N(R′)2, —S(O)R′, —SO2R′, —SO2N(R′)2, —N(R′)2, —NR′C(O)R′, —NR′SO2R′, —X—CN, —X—C(O)R′, —X—C(O)OR′, —X—NR′C(O)OR′, —X—OR′, —X—OC(O)R′, —X—C(O)N(R′)2, —X—S(O)R′, —X—SO2R′, —X—SO2N(R′)2, —X—N(R′)2, —X—NR′C(O)R′,
• wherein each alkyl, alkenyl, and alkynyl can be substituted by one to three substitutents selected from the group consisting of —OR′, ═O, ═NR′, ═N—OR′, —NR′R″, —SR′, -halo, —SiR′R″R′″, —OC (O)R′, —C(O)R′, —CO2R′, —CONR′R″, —OC(O)NR′R″, —NR″C(O)R′, —NR′″C(O)NR′R″, —NR′″SO2NR′R″, —NR″CO2R′, —NHC(NH2)═NH, —NR′C(NH2)═NH, —NHC(NH2)═NR′, —S(O)R′, —SO2R′, —SO2NR′R″, —NR″SO2R′, —CN and —NO2;
• R6 and R7 may be combined to form a (C3-C8)cycloalkyl or (C3-C8)heterocycloalkyl;
• R8 is selected from the group consisting of halogen, —CN, (C1-C6)alkyl, (C1-C6)alkyloxy, and —OH;
• X is a branched or straight chain (C1-C8)alkylene group;
• each occurrence of R′, R″, and R′″ is independently hydrogen or an unsubstituted member selected from the group consisting of (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C4)alkoxy(C1-C4)alkyl, (C1-C8)haloalkyl, (C2-C8)hydroxyalkyl, (C3-C8)cycloalkyl, (C3-C8)heterocycloalkyl, heteroaryl, aryl, (C3-C8)cycloalkyl(C1-C6)alkyl, (C3-C8)heterocycloalkyl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, aryl(C1-C6)alkyl, or two R′ groups, when attached to the same nitrogen atom, can be combined with the nitrogen atom to which they are attached to form a heterocycle or heteroaryl group;
• and
• with the proviso that when R1 is —OH, then R2 and R3 are not both CF3.