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US 8,772,291 B2Granted
Multicyclic compounds and methods of their use
AssigneeLexicon Pharmaceuticals, Inc.
InventorsJoseph Barbosa, Li Dong, Cynthia Anne Fink, Jiancheng Wang, G. Gregory Zipp
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Abstract
This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use in, for example, the treatment of cognitive disorders.
Claims18
A compound of the formula
- or a pharmaceutically acceptable salt thereof, wherein:
- each of E1, E2 and E3 is independently N or CR2;
- each of G1 and G2 is independently N or CR3;
- each of R1, R2 and R3 is independently hydrogen, halogen, cyano, RA, ORA, C(O)RA, C(O)ORA, C(O)N(RARB), N(RARB), or SO2RA;
- each R5 is independently halogen, cyano, RA, ORA, C(O)RA, C(O)ORA, C(O)N(RARB), N(RARB), or SO2RA;
- each RA is independently hydrogen or optionally substituted alkyl, aryl, arylalkyl, alkylaryl, heterocycle, heterocycle-alkyl, or alkyl-heterocycle;
- each RB is independently hydrogen or optionally substituted alkyl, aryl, arylalkyl, alkylaryl, heterocycle, heterocycle-alkyl, or alkyl-heterocycle;
- and
- n is 0-5.
6 more elements
A compound or a pharmaceutically acceptable salt thereof, wherein the compound is (3′-chlorobiphenyl-4-yl)(1-(pyrimidin-2-yl)piperidin-4-yl)methanone.
Dependencies are inferred from the claim text.