Alpha-arylmethoxyacrylate derivative, preparation method thereof, and pharmaceutical composition containing same

A method for treating pancreatic cancer, psoriasis, diabetic retinopathy, or macular degeneration in a subject in need thereof, comprising administering to the subject an alpha-arylmethoxyacrylate of the following formula 1, or a pharmaceutically acceptable salt, a hydrate, or a solvate thereof:

• wherein
• R1 and R5 are each independently H, hydroxy, halogen, C1-6alkyl, or C1-6alkoxy;
• R2, R3 and R4 are each independently H, hydroxy, halogen, formyl, C1-6alkyl, C1-6alkoxy, C3-6 heteroaryl, or any one of formulae A to C:
• wherein
• n is an integer of 0 to 4;
• R11 is H, hydroxy, cyano, C1-4alkyl, C2-6alkenyl, C1-6alkoxy, C1-4alkoxyC1-4alkyl, C3-8cycloalkylC1-4alkyl, or C2-7heterocycloalkylC1-4alkyl, C1-4alkylamino, or diC1-4alkylamino;
• R12 and R13 are each independently H, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C3-8cycloalkylC1-4alkyl, C2-7heterocycloalkylC1-4alkyl, C6-12aryl, C6-12arylC1-4alkyl, C6-12aryloxyC1-4alkyl, or C3-6heteroarylC1-4alkyl, or combine together to form C2-7heterocycloalkyl;
• and
• R14 is H, hydroxy, C3-8cycloalkyl, C2-7heterocycloalkyl, C6-12aryl, C6-12 arylC1-4alkyl, C6-12aryloxy, C3-6heteroaryl, C1-4alkylamino, diC1-4alkylamino, or
• said alkyl, alkenyl and alkoxy each independently being optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, nitro and cyano;
• said cycloalkyl, heterocycloalkyl, aryl and heteroaryl each independently being optionally substituted with one or more substituents selected from the group consisting of halogen, nitro, cyano, C1-4alkyl and C1-4alkoxy;
• and
• said heterocycloalkyl and heteroaryl each independently comprising at least one atom of N or O.