6,7-dihydroimidazo[1,5-a]pyrazin-8(5H)-one derivatives as protein kinase modulators

A compound of the formula (I):

• wherein:
• R1 is —NR3R4 or —OR3;
• R2 is a hydrogen atom or an optionally substituted group selected from straight or branched C1-C6 alkyl, aryl, heteroaryl, aryl C1-C6 alkyl and heteroaryl C1-C6 alkyl;
• R3 and R4, the same or different, are each independently hydrogen atom or an optionally substituted group selected from straight or branched C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, cycloalkyl C1-C6 alkyl, heterocyclyl, heterocyclyl C1-C6 alkyl, aryl, aryl C1-C6 alkyl, heteroaryl and heteroaryl C1-C6 alkyl, or R3 and R4, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted 3 to 7 membered heterocyclyl or heteroaryl ring, optionally containing one additional heteroatom or heteroatomic group selected from S, O, N and NH;
• or a pharmaceutically acceptable salt thereof, wherein the optionally substituted group of R2, R3 and R4 is substituted in any of its free positions by 1 to 6 groups, selected from the groups consisting of:
• halogen, nitro, oxo groups (═O), carboxy, cyano, C1-C6 alkyl, polyfluorinated alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, aryl, heteroaryl;
• amino groups and derivatives thereof;
• carbonylamino groups and derivatives thereof;
• hydroxy groups and derivatives thereof;
• carbonyl groups and derivatives thereof;
• and sulfurated derivatives, wherein when R1 is —NR3R4, only one of R3 and R4 are hydrogen and when R1 is —OR3, R3 is not hydrogen.