Nitrogen-containing heterocyclic compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsShigemitsu Matsumoto, Koji Ono, Yusuke Tominari, Taisuke Katoh, Kazuhiro Miwa, Atsushi Hasuoka, Shinichi Imamura
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Abstract
The present invention provides a novel compound having a superior activity as an ERR-α modulator and useful as an agent for the prophylaxis or treatment of ERR-α associated diseases. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
Claims23
A compound represented by the formula
- wherein
- A is a cyclic group optionally having substituent(s);
- La is a bond, —O—, —CO—, —S—, —SO—, —SO2—, —NRL1— or —NRL1—CO—;
- Lb is a bond or a C1-3 alkylene group optionally having substituent(s);
- Lc is a bond, —CO—, —O—CO—, —NRL2—CO—, —SO2— or —NRL2—SO2—;
- RL1 and RL2 are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), a heterocyclic group optionally having substituent(s), a hydroxy group optionally having a substituent, an amino group optionally having substituent(s), or an acyl group;
- ring G is a 4- to 10-membered saturated heterocycle containing one nitrogen atom as a ring-constituting hetero atom, which is optionally bridged and optionally has substituent(s);
- and
- E is a group represented by the formula
- wherein
- X is —S—, —O— or —NRX—;
- and
- R1, R2 and RX are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), a heterocyclic group optionally having substituent(s), a hydroxy group optionally having a substituent, an amino group optionally having substituent(s), or an acyl group, or
- R1 and R2 in combination optionally form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s),
- or a salt thereof.
A compound represented by the formula
- wherein
- A is a cyclic group optionally having substituent(s);
- La is a bond, —O—, —CO—, —S—, —SO—, —SO2—, —NRL1— or —NRL1—CO—;
- Lb is a bond or a C1-3 alkylene group optionally having substituent(s);
- Lc is a bond, —CO—, —O—CO—, —NRL2—CO—, —SO2— or —NRL2—SO2—;
- RL1 and RL2 are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), a heterocyclic group optionally having substituent(s), a hydroxy group optionally having a substituent, an amino group optionally having substituent(s), or an acyl group;
- ring G is a 4- to 10-membered saturated heterocycle containing one nitrogen atom as a ring-constituting hetero atom, which is optionally bridged and optionally has substituent(s);
- and
- E is a group represented by the formula
- wherein
- X is —S—, —O— or —NRX—;
- and
- R1, R2 and RX are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), a heterocyclic group optionally having substituent(s), a hydroxy group optionally having a substituent, an amino group optionally having substituent(s), or an acyl group, or
- R1 and R2 in combination optionally form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s),
- or a salt thereof.
(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one or a salt thereof.
(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-4-[(2-hydroxy-2-methylpropyl)amino]-1,3-thiazol-2(5H)-one or a salt thereof.
(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-4-[(3-hydroxy-2,2-dimethylpropyl)amino]-1,3-thiazol-2(5H)-one or a salt thereof.
N2-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethylglycinamide or a salt thereof.
N2-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-D-serinamide or a salt thereof.
(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-4-{[2-(2-hydroxyethoxy)ethyl]amino}-1,3-thiazol-2(5H)-one or a salt thereof.
Dependencies are inferred from the claim text.