Alkyne benzotriazole derivatives

A compound of Formula I

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is selected from the group consisting of:
• (1) C2-8alkyl,
• (2) C2-8alkenyl,
• (3) C2-8alkynyl,
• (4) C3-6cycloalkyl-(CH2)p—, wherein p is 1, 2, 3 or 4, and
• (5) benzyl, wherein groups (1) to (5) above are optionally substituted with 1 to 3 Ra groups;
• each Ra and R2 is independently selected from the group consisting of:
• halo, OH, C1-4alkyl, C1-4alkoxy, CF3, —OCF3 and —CN;
• Y is selected from the group consisting of:
• halo, CN, C1-4alkyl, C2-4alkenyl and CH3—S(O)k—, wherein said C1-4alkyl and C2-4alkenyl are optionally substituted with hydroxy, oxo and one or more fluoro groups as allowed by valence, and k is 0, 1 or 2;
• X is selected from the group consisting of:
• (1) H;
• (2) C1-8alkyl, C3-8cycloalkyl, C2-8alkenyl or C2-8alkynyl, any of which is optionally substituted with up to 4 substituents selected from R3, said C3-8cycloalkyl further optionally substituted with 1 or 2 oxo groups and said C1-8alkyl further optionally substituted with ═N—OH;
• (3) phenyl, benzyl, benzoylmethyl, heteroaryl, heteroaryl-CH2—, heteroaryl-CH2CH2— or heteroaryl-CH2CH2CH2—, any of which is optionally substituted with up to 4 substituents selected from R3;
• (4) Het, Het-CH2—, Het-CH2CH2— or Het-CH2CH2CH2—, any of which is optionally substituted with up to 4 substituents selected from R3, the Het portions thereof further optionally substituted with 1 or 2 oxo groups;
• each R3 is independently selected from the group consisting of:
• halogen, OH, CN, CF3, R5, OR5, SR5, SOR5, SO2R5, SO2N(R4)2, COR4, CO2R4, CON(R4)2, CON(R4)OR5, N(R4)2, NO2, NR4COR5, NR4CO2R5, NR4—C1-4alkyl-CO2R5, —C1-4alkyl-N(R4)2, —C1-4alkyl-NR4COR5 and —C1-4alkyl-NR4CO2R5;
• each R4 independently represents:
• (1) H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C3-10cycloalkylC1-4alkyl, C3-10cycloalkenyl or C3-10cycloalkenylC1-4alkyl, any of which except H optionally bear up to 5 halogen atoms or OH, CN, CF3 and C1-4alkoxy;
• (2) phenyl, benzyl or heteroaryl, optionally bridged with a methylene, any of which optionally bear up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, carbamoyl, CO2—C1-4alkyl, C1-4alkylamino and di(C1-4alkyl)amino;
• and (3) Het, optionally bridged with a methylene and said Het optionally bearing up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, carbamoyl, CO2—C1-4alkyl, C1-4alkylamino and di(C1-4alkyl)amino;
• or when two R4 group are attached to the same nitrogen atom, they may be joined together with said nitrogen atom to form a non-aromatic monocyclic, a non-aromatic or partially aromatic bicyclic or a non-aromatic spiro-linked heterocyclic system of up to 12 ring atoms which optionally bears up to 4 substitutents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, C1-4alkylamino and di(C1-4alkyl)amino;
• R5 has the same definition as R4 except that R5 is not H;
• each “heteroaryl” independently refers to 5- or 6-membered aromatic monocyclic or 9- or 10-membered aromatic bicyclic ring systems, in which at least one ring atom is selected from N or N-oxide, O and S;
• and
• each “Het” independently refers to nonaromatic or partially aromatic mono- or bicyclic heterocyclic systems of up to 10 ring atoms, in which at least one ring atom is selected from N, O and S, where the sulfur atom may be in the form of the S-oxide or S,S-dioxide.