Treatment of tumors with genetically engineered herpes virus
AssigneeArch Development Corporation
InventorsRalph R. Weichselbaum, Bernard Roizman, Richard J. Whitley
Life of this patent
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Abstract
Disclosed are methods for treating cancer by administering an effective amount of a modified Herpes simplex virus.
Claims6
A method for reducing a non-central nervous system tumor mass comprising the step of administering to an individual suffering from cancer an amount of a Herpes simplex virus (HSV) comprising a modified HSV genome wherein said modification comprises a deletion of a gene dispensable for viral replication in culture and a modification of an inverted repeat region of said HSV genome such that one γ134.5 gene remains intact, said amount of HSV being effective to reduce the non-central nervous system tumor mass and safe for administration to the patient.
Dependencies are inferred from the claim text.