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US 8,772,258 B2Granted
Single walled carbon nanotube/sirna complexes and methods related thereto
AssigneeEnsysce Biosciences Inc.
InventorsD. Lynn Kirkpatrick, Michelle K. Weiss
Life of this patent
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Abstract
The present invention includes single-walled carbon nanotube compositions for the delivery of bioactive agents and methods of making such single-walled carbon nanotube compositions.
Claims12
A method for delivering siRNA to tumorigenic tissue comprising:
- administering via intravenous injection to a subject having tumorigenic tissue an effective amount of a pharmaceutical composition comprising
- one or more short-interfering ribonucleic acid (siRNA) complexed to single-walled carbon nanotubes;
- and
- a pharmaceutically acceptable excipient;
- administering one or more subsequent doses of the pharmaceutical composition about every 12 to 24 hours based on effect without regard to blood plasma concentration levels of the short-interfering ribonucleic acid (siRNA) complexed to single-walled carbon nanotubes.
2 more elements
A method for inhibiting expression of a gene in a subject comprising:
- administering to the subject an effective amount of a pharmaceutical composition comprising:
- an effective amount of one or more short-interfering ribonucleic acid (siRNA) complexed to single-walled carbon nanotubes;
- and
- a pharmaceutically acceptable excipient;
- and administering one or more subsequent doses of the pharmaceutical composition about every 12 to 24 hours based on effect without regard to blood plasma concentration levels of the short-interfering ribonucleic acid (siRNA) complexed to single-walled carbon nanotubes.
2 more elements
A method for delivering siRNA to tumorigenic tissue comprising:
- administering via intravenous injection to a subject having tumorigenic tissue a pharmaceutical composition comprising:
- an effective amount of one or more short-interfering ribonucleic acid (siRNA) complexed to carbon nanotubes;
- and
- a pharmaceutically acceptable excipient.
1 more element
Dependencies are inferred from the claim text.