Codon modified immunogenic compositions and methods of use
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsBarney S. Graham, Teresa R. Johnson
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Abstract
The present invention features immunogenic compositions comprising codon modified genes that encode viral proteins and/or glycoproteins or fragments. The immunogenic compositions of the invention are useful in various methods of treatment, such as preventing or treating viral infection. Also provided in the present invention are kits and instructions for use.
Claims17
An immunogenic composition for eliciting a CD8+ T cell and antibody response comprising a codon-modified gene encoding a Respiratory Syncytial Virus (RSV) F protein, wherein the codon-modified F gene comprises SEQ ID NO:
- 14, 17, or 18.
A nucleic acid molecule comprising a codon-modified gene encoding a Respiratory Syncytial Virus (RSV) F protein, wherein said gene comprises SEQ ID NO:14, 17, or 18.
A vector comprising a nucleic acid molecule selected from the group consisting of SEQ ID NO:
- 14, 17, and 18.
Dependencies are inferred from the claim text.