Compositions and methods for treating ischemia and ischemia-reperfusion injury

A method for treating an ischemic injury or an ischemia-reperfusion injury in a subject in need thereof, comprising administering to the subject at least two doses of a compound represented by the following structural formula:

• or a pharmaceutically acceptable salt thereof, wherein R1 and R2 in the compound are each independently H or a hydrolyzable group and the compound, or pharmaceutically acceptable salt thereof, is at least 90% enantiomerically pure, the method comprising:
• administering to the subject a non-final dose of the compound, or a pharmaceutically acceptable salt thereof, and a final dose of the compound, or a pharmaceutically acceptable salt thereof, prior to the injury, wherein:
• (a) the final dose is administered to the subject at a time point within about two half-lives of the compound prior to the injury;
• and
• (b) the non-final dose is administered to the subject at a time point that is at least about four half-lives of the compound prior to administration of the final dose.