Compositions and methods for treating ischemia and ischemia-reperfusion injury
AssigneeIschemix LLC
InventorsAlexander Baguisi, Reinier Beeuwkes, Ralph Casale, Steven A. Kates, Alan Lader
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Abstract
The present invention relates to compositions comprising a substantially pure compound represented by Structural Formula I: and methods of using such compounds to activate cytoprotective kinases. The values and preferred values of the variables in Structural Formula I are defined herein.
Claims38
A method for treating an ischemic injury or an ischemia-reperfusion injury in a subject in need thereof, comprising administering to the subject an effective amount of a compound represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof, wherein R1 and R2 in the compound are each independently H or a hydrolyzable group, and wherein the compound has a percent optical purity of at least 90% by weight relative to the other stereoisomers.
A method for treating an ischemic injury or an ischemia-reperfusion injury in a subject in need thereof, comprising administering to the subject an effective amount of a compound represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof, wherein R1 and R2 in the compound are each independently H or a hydrolyzable group, and wherein the compound or pharmaceutically acceptable salt thereof is at least 90% enantiomerically pure.
A method for treating a diabetic condition in a subject in need thereof, wherein the diabetic condition is selected from the group consisting of a diabetic neuropathy, a diabetic ulcer, a diabetic mephropathy and a diabetic retinopathy, comprising administering to the subject an effective amount of a compound represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof, wherein R1 and R2 in the compound are each independently H or a hydrolyzable group, and wherein the compound has a percent optical purity of at least 90% by weight relative to the other stereoisomers.
Dependencies are inferred from the claim text.