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US 8,772,248 B2Granted
Drug delivery system
AssigneeKeele University
InventorPatrick Dawson Bailey
Life of this patent
Estimating the term…
Abstract
A compound comprises a thiopeptide, or derivative or analogue thereof, the thiopeptide comprising a C-terminal carboxylic acid group, and a functional group for attachment to a drug, characterized in that the compound is adapted to carry or transport a drug.
Claims11
A drug conjugate comprising a drug molecule covalently bonded to a thiodipeptide, the thiodipeptide having the formula
- wherein the drug molecule is covalently bonded to a functional group of R4, and is selected from the group consisting of an antibiotic, an anticancer drug, an antihistamine, an antihypertensive, an anti-inflammatory, an antimalarial, an antiviral, a beta blocker, a bronchodilator, a cholesterol lowering agent, a Central Nervous System (CNS) drug, a sedative, and a steroid, wherein R4 is
- a side chain group of serine, glutamic acid, or aspartic acid, wherein R1 is independently selected from a group consisting of:
- a hydrogen;
- and
- a methyl.
2 more elements
A drug conjugate molecule, being a product of the reaction of a functional group of a thiodipeptide with a drug molecule, wherein the thiodipeptide has the formula:
- in which R4 comprises the functional group that reacts with the drug molecule to covalently attach the drug molecule to the thiodipeptide,
- wherein R4 is
- a side chain group of serine, glutamic acid, or aspartic acid, wherein R1 is independently selected from a group consisting of:
- a hydrogen;
- and
- a methyl;
- wherein the drug molecule is selected from the group consisting of an antibiotic, an anticancer drug, an antihistamine, an antihypertensive, an anti-inflammatory, an antimalarial, an antiviral, a beta blocker, a bronchodilator, a cholesterol lowering agent, a Central Nervous System (CNS) drug, a sedative, and a steroid.
4 more elements
Dependencies are inferred from the claim text.