Tubulin inhibitors

Compound of formula (I):

• wherein
• R is H or an alkyl, alkenyl, alkynyl, CO-alkyl or heteroalkyl group, all of which may optionally be substituted;
• R′ is H or an alkyl, alkenyl, alkynyl, CO-alkyl or heteroalkyl group, all of which may optionally be substituted;
• R″ is a group of formula —CH2OH or
• n is 0, 1, 2, 3, 4 or 5;
• Y is independently optionally substituted alkyl, heteroalkyl, halogen, CN, NO2 or OH;
• or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof.