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US 8,772,240 B2Granted
Ethanol dependence of alpha1 antitrypsin C-terminal lys truncation by basic carboxypeptidases
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsPeter Matthiessen, Alfred Weber, Peter Turecek, Hans-Peter Schwarz
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Abstract
Methods of preparing alpha-1-antiproteinase inhibitor and controlling the amount of des-lys alpha-1-antiproteinase inhibitor in the preparation, and compositions comprising the same, as well as methods of treatment using the same are provided.
Claims11
A method of making an alpha-1-proteinase inhibitor composition comprising des-lys aloha-1 proteinase inhibitor from human plasma, the method comprising the step of:
- treating a plasma precipitate comprising alpha-1-proteinase inhibitor with ethanol at a concentration of from 30% to 50%,
- wherein the plasma precipitate is selected from the group consisting of a Cohn fraction IV-1 precipitate and a Cohn fraction IV-1+IV-4 precipitate, and
- wherein the amount of des-lys alpha-1-proteinase inhibitor is increased.
Dependencies are inferred from the claim text.