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US 8,772,229 B2Granted
Methods for synthesis and uses of inhibitors of ghrelin O-acyltransferase as potential therapeutic agents for obesity and diabetes
AssigneeThe Johns Hopkins University
InventorsPhilip A. Cole, Bradley P. Barnett, Yousang Hwang, Jef D. Boeke
Life of this patent
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Abstract
The invention provides inhibitors of ghrelin O-acyltransferase, and methods of making and using them. In some embodiments, the invention provides bisubstrate analog inhibitors of ghrelin O-acyltransferase, which can be effective in treating, for example, obesity and diabetes mellitus.
Claims17
A compound of the formula (I):
- wherein R is absent, or is an organic moiety selected from the group consisting of a substituted or unsubstituted alkyl group, and a substituted or unsubstituted peptide chain and wherein TAT is the peptide shown in SEQ ID NO:3.
Dependencies are inferred from the claim text.