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US 8,772,042 B2Granted
Biomarkers for diagnosing alzheimer's disease
AssigneeBayer Intellectual Property GmbH
InventorsÖzkan Yalkinoglu, Gerhard König, Denis Francois Hochstrasser, Jean-Charles Sanchez, Odile Carrette
Life of this patent
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Abstract
A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific peptide markers, e.g., using mass spectrometric analysis.
Claims5
A method for assessing the state of Alzheimer's disease in a subject, wherein the method comprises detecting in a sample from the subject at least five distinct polypeptides meeting the following criteria:
- a first polypeptide having the amino acid sequence of SEQ ID NO:
- 17;
- a second polypeptide having the amino acid sequence of SEQ ID NO:
- 1 or 2;
- a third polypeptide having the amino acid sequence of SEQ ID NO:
- 3;
- a fourth polypeptide having the amino acid sequence of SEQ ID NO:
- 4, 5, or 6;
- and
- a fifth polypeptide having the amino acid sequence selected from the group consisting of SEQ ID NO:
- 7 to SEQ ID NO:
- 16.
9 more elements
Dependencies are inferred from the claim text.