Enhancement of immune responses by 4-1 BB-binding agents
AssigneeMayo Foundation for Medical Education and Research
InventorsLieping Chen, Scott E. Strome
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Abstract
This invention features methods of enhancing immune responses in mammalian subjects and in vitro methods of enhancing the response of a T cell. Also embodied by the invention are methods of receiving and preventing the induction of energy in T cells.
Claims18
A method of treating a subject that has, or is at high risk of developing, cancer, the method comprising administering to the subject a population of cells comprising an activated T cell obtained by a procedure comprising exposing in culture a cell sample comprising T cells to (i) an immunogenic stimulus, wherein the immunogenic stimulus comprises an immunogenic molecule produced by a tumor cell, or a peptide epitope of such a molecule, but does not comprise a tumor cell, and (ii) an agonistic antibody, or an antibody fragment, that binds to 4-1BB.
Dependencies are inferred from the claim text.