Expression vector for animal cell comprising at least one copy of MAR DNA sequences at the 3′ terminal of transcription termination region of a gene and method for the expression of foreign gene using the vector

An expression vector for an animal cell comprising

• a promoter,
• a cloning site or a polynucleotide encoding a foreign gene product, and
• a transcription terminator,
• all of which are operably connected to each other within the expression vector, wherein the vector comprises a polynucleotide containing nucleotides 4161 to 10134 of SEQ ID NO:2, in which two copies of human β-globulin MAR sequences are connected adjacently to each other, wherein said two copies of human β-globin matrix attachment region (MAR) are located at the 3′ terminal of the transcription terminator.