Protease variants

A variant of a parent protease, comprising a substitution selected from the group consisting of:

• 6C;
• 7P;
• 8C;
• 9C;
• 10E,D;
• 12E,D;
• 13E,D,P;
• 16C;
• 17C;
• 18C;
• 23P;
• 24K,P,R;
• 25K,P,R;
• 27P;
• 32C;
• 33C;
• 37C;
• 39R,K;
• 42E,D;
• 43W;
• 46D,E;
• 47D,E;
• 52C;
• 55C;
• 56R,K;
• 58E,D;
• 62C;
• 63C;
• 67C;
• 69D,E;
• 70D,E;
• 71C;
• 72K,R;
• 76C;
• 81D,E,P;
• 82D,E,P;
• 84D,E;
• 85C;
• 89C,D,E;
• 92P,R;
• 93P;
• 94C,P;
• 95E,D;
• 96E,D,P;
• 97R,K;
• 98P;
• 99R,K;
• 103C;
• 105C,P;
• 106C;
• 111R,K;
• 113E,D;
• 118R,K;
• 120E,D;
• 122K;
• 124R,K;
• 125P;
• 127K;
• 129E,D;
• 130E,D;
• 134C;
• 135P;
• 136P;
• 139C;
• 140E,D;
• 141C;
• 144C;
• 145C;
• 146C;
• 147W;
• 148C;
• 149C;
• 150E,D;
• 151P,E,D;
• 155C;
• 156C;
• 160D,E;
• 161D,E;
• 162K,R;
• 163C;
• 166D,E;
• 170C;
• 172C;
• 173C;
• 174P;
• 175P;
• 176P;
• 180R,K;
• 181R,K;
• 184P;
• 187P;
• and 188R,K
• wherein
• (a) the variant has protease activity;
• (b) each position corresponds to a position of amino acids 1 to 188 of SEQ ID NO:
• 2;
• and
• (c) the variant has a sequence identity to amino acids 1 to 188 of SEQ ID NO:
• 2 of at least 90%.