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AssigneeAjinomoto Co., Inc.
InventorsYasuaki Takakura, Hiroomi Ogino, Masakazu Sugiyama, Kenichi Mori, Eri Tabuchi, Koki Ishikawa, Uno Tagami, Hidemi Fujii
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The present invention provides a methodology for improving a yield of 2R,4R-Monatin. Specifically, the present invention provides a method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin or a salt thereof, comprising isomerizing the 2S,4R-Monatin to form the 2R,4R-Monatin; and the like. These production methods may further comprise condensing indole-3-pyruvate and pyruvate to form the 4R-IHOG, and deaminating a tryptophan to form the indole-3-pyruvate.
A method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R form of 4-(indole-3-yl-methyl)-4-hydroxy-2-oxoglutaric acid (4R-IHOG) with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin,
Dependencies are inferred from the claim text.