Biomarker for osteoarthritis and/or other ageing-related diseases, and use thereof
AssigneeUniversite De Liege
InventorsYves Henrotin, Myriam Gharbi, Michelle Deberg, Edwin De Pauw
Life of this patent
Estimating the term…
Abstract
The invention relates to the identification of a biomarker whose abundance in biological sample is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has applications in the diagnosis of osteoarthritis and/or other ageing-related diseases, in determining the prognosis for an individual diagnosed with osteoarthritis and/or other ageing-related diseases, and in monitoring the efficacy of treatment for osteoarthritis and/or other ageing-related diseases.
Claims12
A method of determining the osteoarthritis status of a subject, and/or the status of another ageing-related disease in a subject, comprising the steps of:
- (i) determining the concentration in a biological sample of a free fragment consisting of amino acid sequence SEQ ID NO:1;
- (ii) comparing the free fragment concentration determined in step (i) with one or more reference values to determine the osteoarthritis status and/or the status of another ageing-related disease in the subject.
A method of diagnosing osteoarthritis and/or another ageing-related disease in a subject, comprising the steps of:
- (i) determining the concentration in a biological sample of a free fragment consisting of amino acid sequence SEQ ID NO:1;
- (ii) comparing the peptide concentration determined in step (i) with one or more reference values to determine the osteoarthritis status and/or the status of another ageing-related disease in the subject.
A method of determining the prognosis for a subject with osteoarthritis and/or another ageing-related disease, comprising the steps of:
- (i) determining the concentration in a biological sample of a free fragment consisting of amino acid sequence SEQ ID NO:1;
- (ii) comparing the free fragment concentration determined in step (i) with one or more reference values to determine the osteoarthritis status and/or the status of another ageing-related disease in the subject.
A kit for use in determining the osteoarthritis status, or the status of another ageing-related disease, in a subject comprising at least one agent for determining the concentration of a free fragment consisting of amino acid sequence of Seq ID No:1, in a biological sample.
An isolated free fragment which consists of amino acid sequence of SEQ ID NO:
- 1, or its amide, or a salt thereof.
Dependencies are inferred from the claim text.