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US 8,771,964 B2Granted
Compositions and methods for detection of methadone metabolite
AssigneeSiemens Healthcare Diagnostics Inc.
InventorBhalchandra Lele
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AssigneeSiemens Healthcare Diagnostics Inc.
InventorBhalchandra Lele
Estimating the term…
Methods and reagents are disclosed for conducting assays for EDDP. The reagents include a moiety selected from the group consisting of poly(amino acid) label moieties, non-poly (amino acid) label moieties, poly(amino acid) immunogenic carriers, non-poly(amino acid) immunogenic carriers, non-label poly(amino acid) moieties, and non-immunogenic carrier poly(amino acid) moieties linked to 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine at the 3-position of one of the phenyl rings. Antibodies produced from immunogenic EDDP conjugates and labeled EDDP conjugates are employed in assays for determining the presence and/or amount of EDDP in samples suspected of containing EDDP.
A compound comprising a moiety, selected from the group consisting of a poly(amino acid) label moiety, a non-poly(amino acid) label moiety, a poly(amino acid) immunogenic carrier moiety, a non-poly(amino acid) immunogenic carrier moiety, a non-label poly(amino acid) moiety and a non-immunogenic carrier poly(amino acid) moiety, linked to 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine at the 3-position of one of the phenyl rings by means of the terminal oxygen atom of the linking group —(CH2)C(O)NH(CH2)(CH2)NHC(O)(CH2)O—.
A compound of the formula:
Dependencies are inferred from the claim text.