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US 8,771,944 B2Granted
Use of micro-RNA as a biomarker of immunomodulatory drug activity
AssigneeCelgene Corporation
InventorsGregory D. Ferguson, Helen Brady, Kyle Chan, Normand R. Richard
Life of this patent
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Abstract
Methods of determining the activity of an immunomodulatory compound by measuring the presence of an miRNA in a sample are disclosed. Additionally disclosed are methods of assessing the patient compliance in patients treated with an immunomodulatory compound.
Claims2
A method for identifying an immunomodulatory compound, comprising:
- a) obtaining a biological sample from a patient;
- b) contacting a cancer cell from the biological sample with the compound;
- c) detecting the presence of a miRNA expression, wherein the miRNA is miR-143, or miR-145 in the cancer cell;
- d) quantifying the level of expression of the miRNA in the cancer cell and the level of the same miRNA in a cell not contacted with the compound;
- and
- e) assessing the difference in the level of the miRNA expression in the cancer cell contacted with the compound and in the cell not contacted with the compound to identify the immunomodulatory compound, wherein an increased level of expression of one or more of the miRNA correlates with an immunomodulatory activity.
3 more elements
Dependencies are inferred from the claim text.