Method for predicting athletic performance potential
AssigneeUniversity College Dublin, National University of Ireland, Dublin
InventorsEmmeline Hill, David MacHugh, Nick Orr, JingJing Gu, Lisa Katz
Life of this patent
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Abstract
A method and assay for predicting athletic performance potential of a subject, such as a thoroughbred race horse, comprising the steps of assaying a biological sample from a subject for the presence of a single nucleotide polymorphism in one or more genes associated with athletic performance. The athletic performance genes may be selected from one or more of MSTN, COX4I2, PDK4, CKM and COX4I1.
Claims25
A method of training a Thoroughbred race horse for optimal racing distance, the method comprising the steps of:
- a) identifying a Thoroughbred race horse that is or may become sufficiently developed for race training,
- b) obtaining a biological sample from the horse,
- c) performing a genotypic analysis of a MSTN-66493737 (T/C) SNP in the biological sample from the horse;
- and
- d) training the horse based on results of the test,
- wherein:
- i) a horse with a C/C genotype in the MSTN-66493737 (T/C) SNP is trained to race as a sprinter,
- ii) a horse with a C/T genotype in the MSTN-66493737 (T/C) SNP is trained to race over middle distances, or
- iii) a horse with a T/T genotype in the MSTN-66493737 (T/C) SNP is trained to race as a stayer.
A method of breeding a Thoroughbred race horse with elite athletic performance potential, comprising the steps of:
- a) obtaining the result of a genotypic analysis of a MSTN-66493737 (T/C) SNP in a biological sample from a Thoroughbred broodmare;
- b) obtaining the result of a genotypic analysis of a MSTN-66493737 (T/C) SNP in a biological sample from a Thoroughbred stallion;
- and
- c) mating the broodmare with the stallion to produce a Thoroughbred offspring;
- wherein:
- i) the broodmare and the stallion each have a homozygous C/C genotype in the MSTN-66493737 (T/C) SNP and the offspring has elite sprinting performance potential,
- ii) the broodmare and the stallion each have a homozygous T/T genotype in the MSTN-66493737 (T/C) SNP and the offspring has stamina performance potential,
- iii) one of the broodmare or stallion has a homozygous T/T genotype in the MSTN-66493737 (T/C) SNP and the other horse in the mating pair has a homozygous C/C genotype in the MSTN-66493737 (T/C) SNP and the offspring has middle distance racing performance potential,
- iv) one of the broodmare or stallion has a homozygous C/C genotype in the MSTN-66493737 (T/C) SNP and the other horse in the mating pair has a heterozygous C/T genotype in the MSTN-66493737 (T/C) SNP and the offspring has either elite sprinting performance potential or middle distance racing performance potential,
- v) one of the broodmare or stallion has a homozygous T/T genotype in the MSTN-66493737 (T/C) SNP and the other horse in the mating pair has a heterozygous C/T genotype in the MSTN-66493737 (T/C) SNP and the offspring has either middle distance racing performance potential or stamina performance potential, or
- vi) the broodmare and the stallion each have a heterozygous C/T genotype in the MSTN-66493737 (T/C) SNP and the offspring has elite sprinting performance potential, middle distance racing performance potential, or stamina performance potential.
A method for detecting the MSTN—66493737 (T/C) single nucleotide polymorphism in an MSTN gene in a horse, comprising:
- performing a nucleic acid-based assay to analyze a nucleic acid from a biological sample obtained from the horse, and detecting in the assay the C allele of the MSTN—66493737 (T/C) single nucleotide polymorphism.
Dependencies are inferred from the claim text.