Implantable medical devices
AssigneeEnbio Limited
InventorsLiam O'Neill, John O'Donoghue, Joe O'Keeffe, Peter Dobbyn
Life of this patent
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Abstract
The present invention is directed to methods for producing a coated substrate, including dissolving at least one biomolecule to form a solution; nebulizing the solution to form a liquid aerosol; combining the liquid aerosol and a plasma to form a coating; and depositing, in the absence of reactive monomers, the coating onto a substrate surface. In an aspect, the substrate can be an implantable medical device.
Claims22
A method of producing a coated substrate, comprising:
- dissolving at least one biomolecule in a solvent to form a solution;
- nebulizing the solution to form a liquid aerosol;
- introducing the liquid aerosol into a plasma;
- and then
- exposing a substrate to the liquid aerosol and the plasma to deposit, in the absence of reactive monomers, a coating comprising the at least one biomolecule onto the substrate.
A method of attaching living cells to a substrate surface, comprising:
- introducing a liquid aerosol comprising a solution of living cells into a non-thermal plasma to form plasma-treated living cells;
- and
- depositing the plasma-treated living cells onto the substrate surface.
A method of producing a coated substrate, comprising:
- dissolving at least one biomolecule in a solvent to form a solution;
- nebulizing the solution to form a liquid aerosol;
- introducing the liquid aerosol into a plasma afterglow;
- and then
- exposing a substrate to the liquid aerosol and the plasma afterglow to deposit, in the absence of reactive monomers, a coating comprising the at least one biomolecule onto the substrate.
A method of producing a coated substrate, comprising:
- dissolving at least one biomolecule in a solvent to form a solution, the at least one biomolecule having biological activity;
- nebulizing the solution to form a liquid aerosol;
- introducing the liquid aerosol into a plasma;
- and then
- exposing a substrate to the liquid aerosol and the plasma to deposit, in the absence of reactive monomers, a coating onto the substrate;
- wherein the coating retains biological activity of the at least one biomolecule.
A method of producing a coated substrate, comprising:
- dissolving at least one biomolecule in a solvent to form a solution;
- nebulizing the solution to form a liquid aerosol;
- introducing the liquid aerosol into a plasma;
- and then exposing a substrate to the liquid aerosol and the plasma to deposit, in the absence of reactive monomers, a coating comprising the at least one biomolecule onto the substrate, wherein the substrate is exposed to the liquid aerosol and the plasma at atmospheric pressure.
Dependencies are inferred from the claim text.