US 8,771,748 B2 · Rapid setting calcium phosphate cements

Abstract

Methods are provided for producing compositions, e.g. pastes or clays, which rapidly set into high-strength calcium phosphate products. In the subject methods, dry reactants that include calcium and phosphate sources, as well as a monovalent cation dihydrogen phosphate salt, are combined with a setting fluid and the combined reactants are mixed to produce the settable composition. A feature of the invention is that cements rapidly set into high strength product compositions. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.

Claims27

Dependent claims

A method of producing a calcium phosphate composition that sets into a calcium phosphate mineral containing product, said method comprising:

combining:
(a) a setting fluid;
(b) dry reactants comprising:
(i) calcium and phosphate sources comprising a first particulate calcium and/or phosphate reactant having a mean particle size of 8 μm or less and narrow particle size distribution;
and a second calcium and/or phosphate reactant having a mean particle size that is 10 μm or greater;
and
(ii) a monovalent cation dihydrogen phosphate salt;
in a ratio of (a) to (b) sufficient to produce said calcium phosphate mineral containing product that is resorbable over time when implanted into a physiological site, wherein the standard deviation of the particles that make up the first reactant does not exceed 4.0 um.

5 more elements

Dependencies are inferred from the claim text.

Rapid setting calcium phosphate cements

Life of this patent

Rapid setting calcium phosphate cements

Life of this patent

Abstract

Claims27