Colloidal suspensions comprising a therapeutic agent and squalene
AssigneeOtonomy, Inc.
InventorsJohn Vinton Schloss, Thomas Jay Lobl
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Abstract
Colloidal suspensions comprising a therapeutic agent and squalene. Squalene binds to certain compounds, such as gacyclidine, much more tightly than other drug carriers, such as polylactic glycolic acid. Including squalene in the particulate phase sequesters the therapeutic agent and provides superior stability at room or body temperature.
Claims3
A colloidal aqueous suspension, comprising nanoparticles that comprise squalene and a therapeutic agent selected from the group consisting of a phencyclidine analog, ifenprodil, traxoprodil, (±)-(R,S)-α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidine propanol, and carbamathione.
Dependencies are inferred from the claim text.