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US 8,771,745 B2Granted
Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof
AssigneeAllergan, Inc.
InventorsMichael R. Robinson, Hui Liu, Patrick M. Hughes, Lon T. Spada, Alazar N. Ghebremeskel
Life of this patent
Estimating the term…
Abstract
Biocompatible, bioerodible implants and microspheres include latanoprost and a biodegradable polymer effective, when placed intraocular (such as into the subtenon space) to treat glaucoma.
Claims1
A method of treating glaucoma, the method comprising anterior sub-tenon administration to a patient with glaucoma of a 50-μl pharmaceutical composition consisting of:
- (a) a plurality of microspheres made from a PLGA and/or PLA;
- (b) 1242 micrograms of latanoprost contained by the microspheres, and;
- (c) 50 μl of a high viscosity hyaluronic acid, the high viscosity hyaluronic acid corresponding to a gel formed of 18 mg of a cross-linked hyaluronic acid in 1 ml of phosphate buffer at pH 7.2, the cross-linked hyaluronic acid having an average molecular weight of about 2 million Daltons, thereby treating the glaucoma.
Dependencies are inferred from the claim text.