Pharmaceutical compositions for poorly soluble drugs
AssigneeMayne Pharma International Pty Ltd.
InventorsDavid Hayes, Angelo M. Morella
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Abstract
The present invention provides a pharmaceutical composition of a practically insoluble drug, wherein the composition may be administered with food or without food. The composition may be in the form of a solid dispersion of the practically insoluble drug and a polymer having acidic functional groups, and the composition may in vitro form a suspension.
Claims25
A pharmaceutical composition comprising a solid dispersion of itraconazole and a polymer having acidic functional groups, wherein during in vitro dissolution testing the composition forms a suspension of a homogeneous dispersion of particles, and wherein the polymer comprises hydroxypropyl methylcellulose phthalate;
- wherein the ratio of itraconazole to polymer is in the range of from 1:1 to 1:3, and the composition provides a mean AUC of at least 800 ng·h/ml after administration in the fasted state.
Dependencies are inferred from the claim text.