Sustained-release hydrogel preparation
AssigneeMedgel Corporation
InventorYasuhiko Tabata
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Abstract
A sustained-release preparation is provided which comprises a drug and a bioabsorbable polymer hydrogel, wherein a concentration gradient of the drug is formed in the hydrogel. Also disclosed is a method of sustained release of a drug in vivo using the sustained-release preparation of the invention. The directionality of the drug release may be controlled by employing the sustained-release preparation of the invention. The sustained-release preparation of the invention is particularly useful as an anti-cancer agent.
Claims14
A sustained-release preparation which comprises:
- a drug having a molecular weight of about 10,000 or less;
- and
- a gelatin hydrogel,
- wherein the drug is impregnated into said gelatin hydrogel through a surface thereof and is immobilized in said hydrogel by physiochemical interaction, and
- said hydrogel having a concentration gradient of the drug such that said concentration gradient being higher at said surface than in other parts of said hydrogel in said sustained-release preparation, and the drug is immobilized within said hydrogel by said physiochemical interaction, thereby controlling the directionality of the sustained release of the drug upon administration of the sustained-release preparation, and
- said sustained-release preparation is sterile.
A method of sustained release of a drug in vivo comprising:
- administering a sustained-release preparation to a patient in need thereof, said preparation comprising a drug having a molecular weight of about 10,000 or less and a gelatin hydrogel, wherein said hydrogel has a concentration gradient of the drug in said sustained-release preparation, wherein degradation of the gelatin hydrogel in vivo causes more drug to be released from a region with higher drug concentration, thereby giving said sustained release of the drug, wherein the drug is impregnated into said gelatin hydrogel through a surface thereof and is immobilized in said hydrogel by physiochemical interaction, said concentration gradient being higher at said surface than in other parts of said hydrogel, and said sustained-release preparation is sterile.
A sustained-release preparation which comprises:
- a drug having a molecular weight of about 10,000 or less;
- and
- a crosslinked gelatin hydrogel,
- said sustained-release preparation being made by adding an aqueous solution of said drug dropwise to said crosslinked gelatin hydrogel, thereby impregnating said drug into said crosslinked gelatin hydrogel through a surface thereof, immobilizing said drug in said crosslinked gelatin hydrogel by physiochemical interaction between said drug and crosslinked gelatin hydrogel, and forming a concentration gradient of the drug in the crosslinked gelatin hydrogel such that said concentration gradient is higher at said surface than in other parts of said hydrogel in said sustained-release preparation, wherein the amount of aqueous solution being added dropwise causes swelling of the crosslinked gelatin hydrogel and wherein said sustained-release preparation is sterile.
Dependencies are inferred from the claim text.