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US 8,771,733 B2Granted
Pharmaceutical composition containing an anti-nucleating agent
AssigneeMerck Sharp & Dohme Corp.
InventorsMaria T. Cruanes, Wei Xu, Laura M. Artino, Honggang Zhu
Life of this patent
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Abstract
Pharmaceutical compositions suitable for oral administration in solid dosage forms are described. The compositions comprise an effective amount of a drug compound in the form of a salt, wherein the drug salt is characterized by conversion to a less soluble form of the drug compound under certain pH conditions, and an anti-nucleating agent.
Claims25
A pharmaceutical composition for oral administration as a solid dose, which comprises:
- (a) from 2 to 15 wt. % of an anti-nucleating agent which comprises a hydroxyalkylcellulose, and (b) from 5 to 75 wt. % of a potassium salt of Compound A, wherein Compound A is:
Dependencies are inferred from the claim text.