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US 8,771,727 B2Granted
Microfluidized oil-in-water emulsions and vaccine compositions
AssigneeZoetis LLC
InventorsPaul J. Dominowski, Ramasamy M. Mannan, Richard L. Krebs, Pamela K. Klose
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Abstract
This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsically. Methods of preparing the emulsions and vaccines are also provided by the present invention.
Claims12
A method of preparing a submicron oil-in-water emulsion, comprising:
- (a) preparing a mixture by combining a light hydrocarbon non-metabolizable oil, one or more surfactants, and an aqueous component;
- (b) subjecting said mixture to a primary emulsification process to produce an oil-in-water emulsion;
- and
- (c) subjecting the oil-in-water emulsion prepared in (b) to microfluidization to produce said submicron oil-in-water emulsion, wherein the submicron emulsion has a mean oil droplet size of less than 1 μm, and wherein the distribution of droplet size is consistently from about 0.03 μm to about 1.0 μm.
1 more element
Dependencies are inferred from the claim text.