Percutaneous absorption enhancer and transdermal preparation using the same
AssigneeToa Eiyo Ltd.
InventorsNaoto Ohtake, Yuuki Koide
Life of this patent
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Abstract
Provided are a percutaneous absorption enhancer excellent in an enhancing effect on percutaneous absorption of a wide range of drugs and excellent in compatibility with an adhesive base, and a transdermal preparation using the percutaneous absorption enhancer. The percutaneous absorption enhancer includes a sulfosuccinate or a salt thereof and an alkyl glycoside or an alkyl thioglycoside.
Claims14
A matrix-type transdermal preparation, comprising:
- a tape comprising drug containing layers comprising an adhesive base,
- a percutaneous absorption enhancer comprising 0.01 to 10% of a sulfosuccinate or a salt thereof and 0.01 to 10% of an alkyl glycoside or an alkyl thioglycoside, wherein the sulfosuccinate or a salt thereof and the alkyl glycoside or the alkyl thioglycoside are present in a total amount of from 0.1 to 20%;
- and
- a drug.
A method of enhancing percutaneous absorption of a drug, the method comprising transdermally administering a matrix-type transdermal tape preparation comprising the drug with a percutaneous absorption enhancer comprising 0.01 to 10% of a sulfosuccinate or a salt thereof, and 0.01 to 10% of an alkyl glycoside or an alkyl thioglycoside, wherein the sulfosuccinate or a salt thereof and the alkyl glycoside or the alkyl thioglycoside are present in a total amount of from 0.1 to 20%.
Dependencies are inferred from the claim text.