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US 8,771,719 B2Granted
Synthesis of a bone-polymer composite material
AssigneeWarsaw Orthopedic, Inc.
InventorsLawrence A. Shimp, John M. Winterbottom, Todd M. Boyce, David Knaack
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Abstract
A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.
Claims26
A composition, comprising:
- a plurality of bone particles having a surface modified with a silane coupling agent;
- wherein the bone particles are about 51% to about 75% by weight of the composition, or the bone particles are about 76% to about 99% by weight of the composition;
- and a polymer precursor selected from a monomer, and a prepolymer, wherein:
- when the polymer precursor is polymerized, at least a portion of the bone particles are covalently attached to the polymerized polymer precursor, at least a portion of the interstitial and vascular structure of the bone particles is infiltrated by the polymerized polymer precursor, or both and the composition comprises a polymer matrix having at least about 60% of the bone particles being elongated and randomly orientated in the polymer matrix and the polymer matrix comprises a biodegradable polyurethane.
1 more element
Dependencies are inferred from the claim text.