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US 8,771,716 B2Granted
Modified release analgesic suspensions
AssigneeMcNeil-PPC, Inc.
InventorsDer-Yang Lee, Jen-Chi Chen, Vincent Chen, Robert Shen
Life of this patent
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Abstract
A pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.
Claims17
A liquid pharmaceutical dosage form comprising:
- a) a first portion comprising ibuprofen and/or pharmaceutically acceptable salts thereof, wherein said ibuprofen is released from the dosage form in a substantially immediate manner upon contact of the dosage form with a dissolution medium;
- and
- b) a second portion comprising:
- i. a phenylephrine-ion exchange resin complex, said phenylephrine-ion exchange resin complex comprising phenylephrine complexed with a sulfonated co-polymer of styrene and divinylbenzene;
- ii. a first coating layer comprising a semi-permeable coating comprising a polymer selected from the group consisting of cellulose acetate, ethylcellulose, non-enteric polymethacrylates and copolymers and mixtures thereof, wherein said semi-permeable coating substantially covers said phenylephrine-ion exchange resin complex;
- and
- iii. a second coating layer comprising a protective coating, wherein said second coating layer covers said first coating layer,
- wherein said phenylephrine is released from the dosage form in a substantially sustained release manner.
5 more elements
Dependencies are inferred from the claim text.