Compositions and methods for treatment
AssigneeSarcode Bioscience Inc.
InventorsJohan Oslob, Wang Shen, Kenneth Barr, Min Zhong
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Abstract
The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.
Claims19
A pharmaceutical composition comprising an effective amount of a compound having the following formula:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle,
- wherein the composition is in the form of liquid drops, liquid wash, gel, ointment, liposomes, solution, cream, powder, foam, crystals, spray, aerosol, or liquid suspension.
A pharmaceutical composition comprising an effective amount of a compound having the following formula:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle,
- wherein the pharmaceutically acceptable vehicle is suitable for ocular administration,
- wherein the composition is formulated as an insert or implant, subconjunctival injection, intraocular injection, periocular injection, retrobulbar injection, or intracameral injection.
Dependencies are inferred from the claim text.