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US 8,771,685 B2Granted
Anti-BV8 antibodies and uses thereof
AssigneeF. Hoffmann-La Roche AG
InventorsXiumin Wu, Yan Wu, Lanlan Yu, Napoleone Ferrara, Wei-Ching Liang, Yu-Ju G. Meng, Janet Tien
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Abstract
The present invention concerns antibodies to Bv8 and the uses of same.
Claims6
An anti-Bv8 antibody comprising a variable domain comprising the following six hypervariable region (HVR) sequences:
- (i) HVR-L1 comprising KASQSX1X2YX3X4X5SYMN, wherein X1 is L or V;
- X2 is D;
- X3 is S or Y;
- X4 is G or H;
- and X5 is D or Y;
- (ii) HVR-L2 comprising AASX1X2EX3, wherein X1 is N;
- X2 is L or R;
- and X3 is S;
- (iii) HVR-L3 comprising QQINEDPFT;
- (iv) HVR-H1 comprising GYX1X2X3X4YDMH, wherein X1 is S;
- X2 is F or L;
- X3 is T;
- X4 is D or N;
- (v) HVR-H2 comprising YIX1X2YX3GX4TX5YNQKFKG, wherein X1 is H or S;
- X2 is S;
- X3 is S;
- X4 is A or S;
- X5 is L or T, and
- (vi) HVR-H3 comprising DX1NYGEAYAMDY, wherein X1 is S,
- or an antigen-binding fragment thereof.
17 more elements
Dependencies are inferred from the claim text.