Method of using salmon thrombin to alleviate pain
AssigneeSea Run Holdings, Inc.
InventorsEvelyn S. Sawyer, Paul A. Janmey, Beth A. Winkelstein
Life of this patent
Estimating the term…
Abstract
A method of alleviating pain associated with tissue damage includes applying salmon thrombin at a tissue damage site, as a single substance in liquid form, or as a powder, a foam, and/or a gel that includes salmon thrombin. A pain relief substance includes a salmon thrombin preparation.
Claims38
A method of alleviating nociceptive pain associated with tissue damage, consisting essentially of administering salmon thrombin at a tissue damage site to slow the rate of protease activated receptor 1 (PAR1) activation at the tissue damage site, as demonstrated by the relative rate at which salmon and human thrombin cleave tetrapeptides based on the activation sites of PAR1, thereby diminishing a degree of pain experienced at the site.
A method of alleviating nociceptive pain associated with tissue damage, consisting of administering salmon thrombin at a tissue damage site, thereby diminishing a degree of pain experienced at the site, wherein diminishing a degree of pain experienced at the site includes providing analgesic relief unrelated to wound healing.
A method of alleviating nociceptive pain associated with tissue damage, consisting of administering salmon thrombin at a tissue damage site, thereby diminishing a degree of pain experienced at the site, wherein diminishing a degree of pain experienced at the site includes providing analgesic relief unrelated to structural repair at the tissue damage site.
A method of alleviating nociceptive pain associated with tissue damage, comprising:
- blotting the tissue damage site, and
- administering salmon thrombin directly to the tissue damage site to slow the rate of protease activated receptor 1 (PAR1) activation at the tissue damage site, as demonstrated by the relative rate at which salmon and human thrombin cleave tetrapeptides based on the activation sites of PAR1.
Dependencies are inferred from the claim text.