Biological material suitable for the therapy of osteoarthrosis, ligament damage and for the treatment of joint disorders

A therapeutic method for the treatment of at least one member selected from the group consisting of osteoarthrosis, cartilagineous defects, bone defects, damaged tendon, damaged ligament, joint disorders, skin lesion and skin ulcers comprising injecting into a subject in need thereof a biological material comprising:

• component (a):
• a liquid carrier comprising a viscous solution containing at least one member selected from the group consisting of natural polysaccharides and semisynthetic polysaccharides, and having a dynamic viscosity of and between 0.1 and 0.25 Pa·s (100 and 250 cPoise) measured at 20° C. at shear rate of D=350 s−1, and/or a Kinematic viscosity comprised between 0.99×10−4 and 2.48×10−4 m2/sec (99 and 248 cSt) measured at 20° C. and at shear rate of D=350 s−1, and
• component (b):
• at least one member selected from the group consisting of (i) a culture or an extemporaneous preparation of mesenchymal stem cells, and (ii) a platelet rich hemo-derivative;
• wherein said viscous solution of the component (a) is selected from the group consisting of:
• (I). an aqueous solution of a hyaluronic acid or a pharmaceutically acceptable salt thereof, with average molecular weight of between 450 and 730 kDa in a concentration of 10 mg/ml, and
• (I). an aqueous solution of hexadecylamide of hyaluronic acid having an average molecular weight in the range of 450 and 730 kDa, in a concentration of between 0.2 and 1.5 mg/ml.