Tctex-1 regulatory sequence as stem cell marker
AssigneeCornell University
InventorsChing-Hwa Sung, Jen-Zen Chuang
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Abstract
The disclosure relates to an isolated regulatory sequence for Tctex-1 that is transcriptionally active in adult neural progenitor and stem cells, including Type 1, Type 2 and Type 3 progenitors, as well as during development. The disclosure also relates to a method for selectively expressing a genetic sequence in neural progenitor cells. The disclosure of inserting and expressing a specific sequence in these cells allows marking, identification, sorting, tracking, and manipulating neural progenitor and stem cells.
Claims8
A vector comprising a nucleic acid encoding a Tctex-1 promoter operably linked to a heterologous nucleic acid, said promoter comprising the nucleotide sequence set forth in SEQ ID NO:
- 1 or SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.