(Trimethoxyphenylamino) pyrimidinyl formulations
AssigneeRigel Pharmaceuticals, Inc.
InventorsBindhumadhavan Gururajan, Farhan Abdul Karim Alhusban, Ian Paul Gabbott, David Bradley Brook Simpson, Dawn Sievwright
Life of this patent
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Abstract
There are provided pharmaceutical compositions comprising greater than 15% w/w of a compound of Formula (I) as defined herein and/or hydrate thereof and an amount of one or more effervescent agents that is sufficient to provide satisfactory in vitro dissolution; and further comprising one or more pharmaceutically acceptable ingredients; and to processes for obtaining them.
Claims8
A solid pharmaceutical composition comprising greater than 15% w/w of the compound of Formula (I):
- wherein each X+ represents a monovalent cation;
- and/or a hydrate thereof;
- and an amount of one or more effervescent agents that is sufficient to provide satisfactory in vitro dissolution at low pH;
- and further comprising one or more pharmaceutically acceptable ingredients.
A unit dosage form comprising greater than or equal to 60 mg of the compound of Formula (I):
- wherein each X+ represents a monovalent cation;
- and/or a hydrate thereof;
- and less than or equal to 110 mg of one or more effervescent agents that is sufficient to provide satisfactory in vitro dissolution at low pH;
- and further comprising one or more pharmaceutically acceptable ingredients.
Dependencies are inferred from the claim text.