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US 8,771,644 B2Granted
Imaging probes
AssigneeSanofi
InventorsKarl-Ulrich Wendt, Maik Kindermann, Anja Globisch
Life of this patent
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Abstract
The present invention relates to molecular probes of the formula (I) {L1-R1-L}n-A-CO—NH—R2-L2 (I) as defined herein that allow for the observation of the catalytic activity of a selected cathepsin in in vitro assays, in cells or in multicellular organisms, a method for their preparation and the use thereof.
Claims15
A molecular probe for cathepsin protease S of the formula (I):
- wherein
- X is —CONH—R2-L2
- Y is-L-R1-L1, and
- R1 and R2 are, independently of each other, each a linker;
- L is a bond or a group allowing for a facile conjugation of the group L1;
- L1 and L2 are, independent of each other, at least one label optionally bound to a solid support.
3 more elements
Dependencies are inferred from the claim text.