Active particles for bio-analytical applications and methods for their preparation

Particle comprising a micelle, which, on its turn, has a substantially hydrophilic shell and a substantially hydrophobic central portion;

• a core, which is located in the area of the micelle central portion and comprises a silicate network;
• and at least an active compound;
• the micelle comprising a plurality of molecules of at least a surfactant, which molecules comprise at least a molecule of a functionalized surfactant having the following structure:
• M1-Hydro1-Lipo-Hydro2-M2
• wherein Lipo represent a substantially hydrophobic chain;
• Hydro1 and Hydro2 represent, independently of each other, a respective substantially hydrophilic chain;
• M1 has the following structure:
• RBM1-BL1-
• wherein RBM1 represents a recognition bio-molecule, BL1 represents a bridge linker chosen in the group consisting of:
• and amide;
• M2 is selected in the group consisting of:
• —H, —OH and the following structure:
• —BL2-RBM2
• wherein RBM2 represents a recognition bio-molecule, BL2 represents a bridge linker chosen in the group consisting of:
• and amide;
• R20 being chosen in the group consisting of:
• —H, a linear alkyl group, a cyclo-alkyl group, an aromatic ring, a hetero-group;
• the surfactant and the active compound are different from each other;
• the molecules of the surfactant comprise a non functionalized surfactant having the following structure:
• Hydro3-Lipo1-Hydro4
• wherein Lipo1 represent a substantially hydrophobic chain;
• Hydro3 and Hydro4 represent, independently of each other, a respective substantially hydrophilic chain;
• the molar ratio between the non functionalized surfactant and the functionalized surfactant is at least 3/1.