Anti-no-reflow guide wire for vascular interventional procedures
AssigneeAdenopaint, LLC
InventorsMervyn B. Forman, Edwin K. Jackson, Jianying Zhang, Zaichuan Mi
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Abstract
The present invention relates to compositions and methods for improving outcomes in vascular interventional procedures. In particular, the present invention relates to compositions and methods for improving outcomes in vascular interventional procedures using an anti-no-reflow guide wire that attenuates the “no-reflow” phenomenon that is associated with negative outcomes.
Claims21
A medical device for attenuating no-reflow phenomenon, comprising
- a cardiac guide wire;
- a polymer or a monomer formed from a polyisocyanate and adenosine, coating at least a portion of the wire;
- and
- optionally, free adenosine, not covalently linked to the polymer or the monomer, but entrapped in the polymer or monomer,
- wherein the polymer or monomer is configured to release adenosine to the blood vessels upon contact between the polymer or monomer and a body fluid, thus causing dilation of blood vessels within five minutes of release.
A medical device for attenuating no-reflow phenomenon, comprising a cardiac guide wire, wherein at least a portion of the wire is coated with a polymer formed by the reaction of an LDI-Adenosine monomer with an LDI-Glycerol monomer, wherein the device is configured to release adenosine to the blood vessels upon contact with a body fluid, thus causing dilation of blood vessels.
A medical device for attenuating no-reflow phenomenon, comprising a cardiac guide wire, wherein at least a portion of the wire is coated with a polymer formed by polymerization of an Adenosine-LDI-Cysteine monomer, wherein the device is configured to release adenosine to the blood vessels upon contact with a body fluid, thus causing dilation of blood vessels.
Dependencies are inferred from the claim text.