Hemostatic sponge
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsHans Christian Hedrich, Joris Hoefinghoff, Woonza M. Rhee, Atsushi Edward Osawa
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Abstract
The present invention provides a hemostatic composite sponge comprising a porous matrix of a biomaterial and a material enhancing the adherence of said sponge to the applied tissue stably associated with at least one surface of said sponge, a method of producing these sponges and their use in hemostasis.
Claims26
A hemostatic composite sponge comprising a porous sponge of a matrix of a biomaterial and a material enhancing the adherence of said porous sponge to an applied tissue stably associated with at least one surface of said porous sponge, wherein said adherence-enhancing material is essentially free of a hydrogel forming component, wherein the adherence-enhancing material comprises a first cross-linkable component and a second cross-linkable component, wherein the first cross-linkable component includes multiple nucleophilic groups and the second cross-linkable component includes multiple electrophilic groups, and wherein the first cross-linkable component and the second cross-linkable component are polymerized to form a polymer.
A method of manufacturing a hemostatic composite sponge comprising:
- providing a porous sponge of a matrix of a biomaterial;
- providing a material enhancing the adherence of said porous sponge to an applied tissue in the form of a suspension, a solution or powder, wherein said material is essentially free of a hydrogel forming component, and wherein the material comprises a first cross-linkable component and a second cross-linkable component that are polymerized to form a polymer;
- and
- contacting the porous sponge and the material so that the material is stably associated with at least one surface of said porous sponge so that the hemostatic composite sponge is obtained.
A hemostatic composite sponge comprising:
- a porous sponge of a matrix of a biomaterial;
- and
- a material enhancing the adherence of the porous sponge to an applied tissue stably associated with at least one surface of the porous sponge,
- wherein the material is essentially free of a hydrogel forming component, wherein the material comprises a first cross-linkable component and a second cross-linkable component, and wherein there is cross-linking between the two cross-linkable components and the porous sponge.
A method of manufacturing a hemostatic composite sponge, the method comprising:
- providing a porous sponge of a matrix of a biomaterial;
- providing a material enhancing the adherence of the porous sponge to an applied tissue in the form of a suspension, a solution, or powder, wherein the material is essentially free of a hydrogel forming component, and wherein the material comprises a first cross-linkable component and a second cross-linkable component;
- and
- contacting the porous sponge and the material so that the material is stably associated with at least one surface of the porous sponge, and there is cross-linking between the two cross-linkable components and the porous sponge, so that the hemostatic composite sponge is obtained.
A method of using a hemostatic composite sponge to treat a patient, the method comprising:
- administering the hemostatic composite sponge to a treatment site of the patient,
- wherein the hemostatic composite sponge comprises a porous sponge of a matrix of a biomaterial, and a material enhancing the adherence of the porous sponge to an applied tissue stably associated with at least one surface of the porous sponge, wherein the material is essentially free of a hydrogel forming component, wherein the material comprises a first cross-linkable component and a second cross-linkable component, and wherein there is cross-linking between the two cross-linkable components and the porous sponge.
Dependencies are inferred from the claim text.