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US 8,709,445 B2Granted
Vaccination with killed but metabolically active (KBMA) protozoans with toll-like receptor agonists
AssigneeLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
InventorsNoah A. Craft, Kevin W. Bruhn, Ron A. Birnbaum
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Abstract
This invention provides compositions for inducing an immune response in a vertebrate host against a protozoan parasite. In certain embodiments the composition comprises a protozoan parasite comprising a psoralen-modified DNA, whereby said protozoan parasite is killed but metabolically active (KBMA); and optionally a Toll-like receptor agonist.
Claims12
A composition for inducing an immune response in a vertebrate host against a protozoan parasite, said composition comprising:
- a protozoan parasite comprising a psoralen-modified DNA, whereby said protozoan parasite is killed but metabolically active (KBMA);
- wherein said composition is formulated for administration to a vertebrate;
- and
- when administered to a vertebrate induces an immune response in said vertebrate where said immune response is directed against the protozoan parasite.
1 more element
Dependencies are inferred from the claim text.